![]() ![]() Mahadeo D, Kaplan L, Chao MV, Hempstead BL. Neurotrophins and their receptors: a convergence point for many signalling pathways. The p75 neurotrophin receptor: multiple interactors and numerous functions. BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation. 1996 16(10):3123–9.įulgenzi G, Tomassoni-Ardori F, Babini L, Becker J, Barrick C, Puverel S, et al. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. 2014 220:103–19.Įide FF, Vining ER, Eide BL, Zang K, Wang XY, Reichardt LF. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. 1991 6(5):845–58.īerkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV, Rosenthal A. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Ip NY, Ibanez CF, Nye SH, McClain J, Jones PF, Gies DR, et al. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Maisonpierre P, Belluscio L, Squinto S, Ip N, Furth M, Lindsay R, et al. Identification and characterization of a novel member of the nerve growth factor /brain-derived neurotrophic factor family. Purification of a new neurotrophic factor from mammalian brain. Viktor Hamburger and Rita Levi-Montalcini: the path to the discovery of nerve growth factor. Regulation of neuronal survival and death by extracellular signals during development. The neurotrophic hypothesis: where does it stand? Philos Trans R Soc B Biol Sci. Neurotrophins: Roles in neuronal development and function. Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. ![]() 2000 23:73–87.Ĭecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P. Apoptosis in neural development and disease. Caspase activation, inhibition, and reactivation: a mechanistic view. Programmed cell death in neurodevelopment. Mechanisms of programmed cell death in the developing brain. Programmed cell death and apoptosis - where it came from and where it is going: from Elie Metchnikoff to the control of caspases. Tumor necrosis factor receptor-associated factor Trk: Sortilin-related VPS10 domain containing receptor 2 SOS: Neurotrophin receptor interacting factor NT-3: Neurotrophin receptor-interacting melanoma antigen gene homolog NRIF: N-methyl D-aspartate receptor subtype 2B NRAGE: Mini excitatory postsynaptic current mRNA: Growth factor receptor-bound protein 2 IPSC: Glial cell line-derived neurotrophic factor GRB2: Guanine-nucleotide dissociation inhibitor GDNF: Brain-derived neurotrophic factor (BDNF)Īpoptotic protease activating factor 1 ASD:ĬAMP response element-binding protein Cyt c:Į26 transformation-specific-like protein 1 E-LTP:Įpidermal growth factor receptor kinase substrate 8 ERK:Įxtracellular signal-regulated kinase FADD:įas-associated protein with death domain FRS2:įibroblast growth factor substrate 2 GABA:.Dysregulation of neurotrophins or their receptors at critical stages during development results in neurodevelopmental disorders that arise from perturbations in neuronal survival, proliferation, differentiation, synaptic function, connectivity, and plasticity. In addition to controlling the balance between neuronal survival and cell death, neurotrophins regulate neuronal differentiation, connectivity and function, making them essential for proper nervous system development. The four members of this family, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4), have unique expression patterns and act through their receptors on distinct neuronal populations at different stages throughout development and in adulthood. Cell death is regulated by a family of secreted proteins known as the neurotrophins. Throughout development, this initial surplus of cells is reduced and the connections between them refined via tightly controlled cell death. Early in development, the nervous system overproduces neurons and synapses. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |